custom fonts rendering is always a tiny bit different in Chrome, the characters appear a little more thick and blurry, but the difference should be really small, if you are seeing a serious difference, then there is something else on your end.
Well yes, but blurry (pixelated is how I would describe it) fonts in something as important as the main menus is a pretty bad thing. Its not a huge thing, but its certainly noticeable immediately and looks unprofessional.
Is there any workaround for this? If not, going fwd I would strongly suggest avoiding custom fonts on your end.